AD neuropathologic change

Last updated: August 6, 2025

The updated National Institute on Aging-Alzheimer’s Association criteria is based on consensus recommendations for postmortem diagnosis of Alzheimer’s disease. The criteria rely on a combination of neurofibrillary tangles (Braak), neuritic plaque score (CERAD), and Amyloid beta plaque score (Thal). The neuropathologist determines the level of AD pathology.

Source: https://www.radc.rush.edu/docs/var/detail.htm?category=Pathology&subcategory=Alzheimer%27s+disease&variable=adnc