About ROSMAP Compass
Exploring single-cell genomics in aging and Alzheimer's Disease
ROSMAP-Compass
Aging, Alzheimer’s Disease (AD), and neurodegeneration are among the most pressing challenges in healthcare. Thanks to rapid advances in single-cell genomics, researchers now have powerful tools to dissect complex tissues at unprecedented resolution, revealing key molecular and cellular processes that drive disease. Large-scale datasets, such as those generated by the Religious Order Study and Rush Memory and Aging Project (ROSMAP), provide an invaluable resource for understanding the biology of aging and neurodegeneration.
Here, we present ROSMAP-Compass—a user-friendly webserver empowering investigators to explore 7.5 million sequenced single cells with over one billion precomputed gene-level tests. By leveraging the state-of-the-art T2T genome reference for realignment and implementing rigorous measures to eliminate data leakage and duplicated cells, ROSMAP-Compass ensures high-quality data integration. This unified platform facilitates deeper insights into AD pathogenesis and aging by making cutting-edge single-cell analyses more accessible to the broader research community.
FAQ
⚠️ This website is under active development ⚠️
1. What conditions have been investigated?
We have primarily focused on Alzheimer’s Disease and related neurodegenerative conditions, leveraging single-cell data from individuals across varying levels of cognitive impairment.
2. How many cells are present?
There are 7.5 million single cells included in this dataset, enabling comprehensive analyses of cellular heterogeneity in brain tissue.
3. How can I contact the authors?
For inquiries, collaborations, or support, please email the corresponding authors at andreas.keller[at]ccb.uni-saarland.de.
4. What data quality measures are in place?
All samples are realigned against the T2T genome reference to reduce errors. Extensive checks ensure no duplicated cells or data leakage.
5. How can I access and analyze the data?
ROSMAP-Compass provides an intuitive web-based interface, allowing you to query gene-level data, generate customizable plots, and download results for more in-depth analysis.
6. Is there any cost or registration required?
No, the service is free to use, but we may require brief registration for tracking usage and updates.
7. Where to get the raw data?
Below is a table of recent publications from the ROSMAP cohort. Each row links to the relevant Synapse ID, where raw single-nucleus RNA sequencing (snRNA-seq) data can be accessed.
| Year | Author | DOI | Cohort | Synapse ID (snRNA-seq) |
|---|---|---|---|---|
| 2022 | Blanchard et al. | https://doi.org/10.1038/s41586-022-05439-w | ROSMAP | syn2580853 |
| 2023 | Mathys et al. | https://doi.org/10.1016/j.cell.2023.08.039 | ROSMAP | syn2580853 |
| 2024 | Mathys et al. | https://doi.org/10.1038/s41586-024-07606-7 | ROSMAP | syn52293417 |
| 2024 | Fujita et al. | https://doi.org/10.1038/s41588-024-01685-y | ROSMAP | syn2580853 |
| 2025 | De Jager Lab | - | ROSMAP | syn52339332 |
8. How should I cite ROSMAP-Compass?
Please cite the original ROSMAP publications along with any forthcoming ROSMAP-Compass references when using this resource in your research.
Thank you for using ROSMAP-Compass!